During production, numerous materials, including biologically sourced materials, are combined in a series of robust process steps to produce a final vaccine. In the upstream process (USP), the biological source organism is amplified to make a crude harvest. In the downstream process (DSP), the crude intermediate product – typically recombinant antigens or entire pathogens – is purified to yield a bulk vaccine product. The final formulation completes the production process by, for example, combining antigens and adjuvant into a defined stable formulation for long-term storage.
Intravacc’s manufacturing specialists have developed scalable upstream and downstream biomanufacturing processes with cells, viruses, and bacteria for over 20 years. With expertise and excellence in a multitude of production processes, our team is ready to optimize your vaccine development.