Scientific publications

Formaldehyde treatment of proteins enhances proteolytic degradation by the endo-lysosomal protease cathepsin S

Thomas J M Michiels, Hugo D Meiring, Wim Jiskoot, Gideon F A Kersten, Bernard Metz

A great number of laboratory animals are still being used all over the world for the quality control of vaccines. This also applies for tetanus and diphtheria vaccines, both consisting of bacterial toxins inactivated by formaldehyde. This inactivation largely determines the quality of these vaccines. Researchers from Intravacc and LACDR have been searching for a test that reduces the use of laboratory animals. For more information, see our press release 

Prevalent levels of RSV serum neutralizing antibodies in healthy adults outside the RSV-season

Johan L Van Der Plas, Pauline Verdijk, Emilie M J Van Brummelen, Rienk E Jeeninga, Meta Roestenberg, Jacobus Burggraaf, Ingrid M C Kamerling

Slc22a5 haploinsufficiency does not aggravate the phenotype of the long-chain acyl-CoA dehydrogenase KO mouse

Pablo Ranea-Robles  , Chunli Yu, Naomi van Vlies, Frédéric M Vaz, Sander M Houten

Intranasal immunization with outer membrane vesicle pertussis vaccine confers broad protection through mucosal IgA and Th17 responses

René H M Raeven , Dedeke Rockx-Brouwer, Gaurav Kanojia, Larissa van der Maas, Tim H E Bindels, Rimko Ten Have, Elly van Riet, Bernard Metz

Hyaluronan molecular weight: Effects on dissolution time of dissolving microneedles in the skin and on immunogenicity of antigen

Mara Leone, Stefan Romeijn, Bram Slütter, Conor O'Mahony, Gideon Kersten, Joke A Bouwstra

In silico identification and modification of T cell epitopes in pertussis antigens associated with tolerance

Corine Kruiswijk, Guilhem Richard, Merijn L M Salverda, Pooja Hindocha, William D Martin, Anne S De Groot, Elly Van Riet

Identification of Naturally Processed Mumps Virus Epitopes by Mass Spectrometry: Confirmation of Multiple CD8+ T-Cell Responses in Mumps Patients

Jelle de Wit, Maarten E Emmelot, Hugo Meiring, Jacqueline A M van Gaans-van den Brink, Cécile A C M van Els, Patricia Kaaijk

Identification of Formaldehyde-Induced Modifications in Diphtheria Toxin

Bernard Metz, Thomas Michiels, Joost Uittenbogaard, Maarten Danial, Wichard Tilstra, Hugo D Meiring, Wim E Hennink, Daan J A

Activation of Human Monocytes by Colloidal Aluminum Salts

Hilde Vrieling, Sietske Kooijman, Justin W de Ridder, Dominique M E Thies-Weesie, Peter C Soema, Wim Jiskoot, Elly van Riet, Albert J R Heck, Albert P Philipse, Gideon F A Kersten, Hugo D Meiring, Jeroen L Pennings, Bernard Metz 

Quantitative CPP Evaluation from Risk Assessment Using Integrated Process Modeling

Daniel Borchert, Thomas Zahel, Yvonne E Thomassen, Christoph Herwig, Diego A Suarez-Zuluaga