In vitro alternative assay to the replace rabbit pyrogen test for vaccines.
Intravacc, in close collaboration with MAT services at Sanquin Diagnostic Services, announced the publication of a scientific article of an in vitro alternative assay to the replace rabbit pyrogen test for vaccines. Vaccines are essential for public health, but safety is paramount. The rabbit pyrogen test (RPT) is traditionally used, but a new in vitro Monocyte Activation Test (MAT) proves to be a robust alternative. The study highlights MAT’s efficacy in determining the reactogenicity of Outer Membrane Vesicle (OMV) vaccines, even in developmental phases. Avacc® 3, an OMV vaccine for Bordetella Pertussis, demonstrated desired safety profiles with both MAT and RPT. Published in Scientific Reports, Volume 13, 2023, the article signifies a significant leap in vaccine safety testing.