Structure
Biosensor and LC-MS analysis
Structural integrity is essential for the correct functioning or immune response-inducing properties of a drug substance. Biosensor and LC-MS analysis provide valuable insights.
- Solve or determine the primary structure (protein sequence, LPS structure)
- Assess the secondary and tertiary structure (protein folding)
- Identify post-translational modifications (PTMs): glycosylation, oxidation, deamidation
- Detect sequence variants and subspecies
- Measure antigen binding and affinity
- Determine thermal unfolding transitions (Tm)
- Structural elucidation and identification of unknown chromatographic peaks